In this study, the team went to 53BP1 Biological function Especially when mediating the structure of DNA Heterochromatin.
Researchers have discovered that this new function involves the activity of a new form of 53BP1 in which proteins accumulate in condensed DNA regions and form small droplets. This is a process called liquid-liquid phase separation, similar to mixing oil and water in a salad dressing. ..
The team has determined how 53BP1 can form droplets. They found that this process required the involvement of other proteins known to support the structure of highly condensed DNA. But in turn, they found that 53BP1 actually stabilized the collection of these proteins in these DNA regions. This is important for maintaining the overall function of DNA.
A detailed molecular analysis was then performed to break down the large protein into smaller pieces to determine the pieces important for the droplet formation of 53BP1. They also modified the amino acids at specific positions in the 53BP1 protein and determined the contribution of several amino acids important to this new function.
“More excitingly, through these comprehensive analyzes, this new protective activity of 53BP1 is independent of the widely known role of this protein in repairing DNA damage and exhibits a whole new function of 53BP1. “We do,” said Zhang. “Our study suggests that in addition to DSB repair regulation, 53BP1 contributes to the maintenance of genomic stability through the formation of these droplets.”
With this new information, Zhang and his team will better understand how to prevent diseases such as cancer and even design treatments to treat cancer using this new feature of 53BP1 in the future. I want it.
Zhang’s lab focuses on understanding cell biology and developing anti-cancer therapies. Specifically, how cells protect the stability of DNA. Without that protection, DNA can cause genomic instability, ultimately leading to early onset of degenerative diseases such as premature aging and cancer.
“Our goal is to understand the molecular mechanisms that maintain the genomic stability of human cells by identifying the genes involved and signaling pathways. In the long run, this knowledge is a potential anti-virus. I want to convert it into a therapeutic strategy. ”
